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Cluster Headache and Medical Cannabis

Cluster headache causes debilitating attacks of pain, which typically occur at the same time each day for several weeks. Known for causing intense, one-sided pain around the eye or temple, the attacks can last anywhere from 15 minutes to several hours. Cluster headache is relatively rare, and first line treatments are available to lessen the pain and help prevent future attacks. For patients who have not found relief, medical cannabis may be an option to explore for cluster headache. 

What Causes Cluster Headache?

A man sitting on a sofa with his hands pressing against the side of his head, as if trying to relieve a headache
Risk factors for developing cluster headache include male sex, a family history, and prior head injury.

There are certain triggers, but the exact cause is unknown. Triggers include:

  • Consumption of alcohol during a bout of attacks
  • Strong-smelling chemicals such as perfume/aftershave, petrol, paint and other DIY products (typically those containing Volatile Organic Compounds ).
  • Overheating during exercise
  • Smoking

Cluster Headache Symptoms

A woman sat at a desk. She is holding her hand against her forward, as if trying to relieve a headache. There is a laptop on the desk. Cluster headache is characterised by excruciating pain, typically on one side of the head around the eye area or the temple. The pain is often felt on the same side of the head during each attack and is typically severe and disabling. An attack can lead to the sufferer rocking, pacing or even banging one’s head against the wall.

Additional possible symptoms of cluster headache include:

  • A red, watering eye on the affected side
  • The drooping/swelling of the eyelid on the affected side
  • A smaller pupil in the eye on the affected side
  • Sweating
  • A blocked or runny nostril, again, on the affected side
  • Nausea and vomiting

Cluster Headache Prevention

There are preventative treatments for cluster headache. The first line preventative treatment is a calcium-channel blocker called verapamil which is taken orally, however other medications and even surgery may play a role for some individuals. Preventative treatment may be necessary for those who experience chronic cluster headaches to ensure they can lead a normal life.

Cluster Headache Treatment

A pharmacist in a white coat stands, looking at a woman who is standing with her hands pressed against her temple as if showing where there is pain Over-the-counter pain relief is not typically effective for cluster headache. Specialist treatments and medication for cluster headache are available and should be implemented as soon as an attack begins. These include:

  • Sumatriptan injections – usually effective within 15 minutes, can be injected twice daily
  • Sumatriptan or zolmitriptan nasal spray – a fast-acting alternative to injections if preferred
  • Oxygen therapy whereby one breathes pure oxygen through a face mask. Studies suggest the use of oxygen for cluster headache works by contracting the cerebral vessels which widen during a cluster headache attack.

Medical Cannabis for Cluster Headache

The pain of cluster headache can be difficult to manage and may in particular disrupt your sleep. It is important to speak to your GP as soon as possible if you suspect you have had or are experiencing cluster headache. You can read the latest evidence on cluster headache from the UK Medical Cannabis Registry, which shows a change in headache frequency and/or severity for some individuals prescribed medical cannabis at Curaleaf Clinic.

We’re here to help you explore what’s right for you and your condition. If you are exploring medical cannabis for cluster headache, register with Curaleaf Clinic to check your eligibility for a consultation and speak to a doctor who specialises in this specific type of pain.

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Frequently Asked Questions about Cluster Headache

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Cluster headache is characterised by excruciating attacks of pain in the head, usually on one side of the head around the eye or temple.

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There is no evidence of cluster headache being life-threatening, however, they are excruciatingly painful and can cause disorientation and irrational behaviour due to the severity of the pain.

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You will experience agonising pain, usually in one side of the head that lasts anywhere from 15 minutes to a few hours. Unlike other headaches, the pain from a cluster headache is reported to be unbearable and cannot be relieved using over-the-counter medications.

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There are a few treatment options to relieve cluster headaches at home, these are:

  • Sumatriptan injections, sumatriptan or zolmitriptan nasal spray, or oxygen therapy.
  • In addition to treatment of acute attacks, it is also important to avoid exacerbating factors, such as smoking.
  • Finally, preventative medications and/or surgery may be applicable for certain individuals.
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Drinking water during a cluster headache is not known to directly relieve symptoms.

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Remission from cluster headache is normal and can last months or even years. Some people report having experienced one bout of cluster headaches without recurrence, other sufferers experience them daily in bouts that last for weeks or months at a time before they go back into remission. Recurrences and periods of remission vary from person to person.

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A cluster headache attack typically lasts between 15 and 180 minutes.